鄭仁坤 主任

鄭仁坤, Jen-Kun Cheng, MD, PhD.

20140904091651

  • E-mail: jkcheng@usa.net

 

Address of my Website:

http://www.medicine.mmc.edu.tw/Teacher_Detail.asp?hidPage1=2&hidPeopleCatID=1&hidPeopleID=132

 

EDUCATION and TRAINING

July 1983-June 1990, Yang-Ming Medical College, MD, Taipei, Taiwan

July 1992-July 1996, Residency, Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan

August 1998- July 1999, Research Fellow, Department of Anesthesiology, Wake Forest University School of Medicine, North Carolina, USA

July 2001-June 2005, Institute of Pharmacology, College of Medicine, National Taiwan University, PhD.

April 18-21, 2006, Preceptorship (ultrasound guided regional anesthesia), Toronto Western Hospital, Canada.

April 22-26, 2006, Workshop (International Society of Ultrasound and Regional Anesthesia, ISURA), Toronto, Canada.

July 2007-June 2008, Research Fellow, Pain Research Center, Department of Anesthesiology, Brigham and Women’s Hospital, Boston, MA, USA

 

POSITION

August 1996-now, Staff Anesthesiologist, Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.

July 2009-June 2011, Operating Room Director, Mackay Memorial Hospital, TamShui branch, New Taipei City, Taiwan.

July 2011-June 2015, Chairman, Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.

July 2011- June 2015, Operating Room Director, Mackay Memorial Hospital, Taipei, Taiwan.

August 2012-now, Associate Professor, Mackay Junior College of Medicine Nursing and Management, Mackay Medical College, New Taipei City, Taiwan.

 

CERTIFICATION
National Boards of Medical Examiners of R.O.C. # 020173, 1991
Certified, R.O.C. Board of Anesthesiology # 0501, 1996
Acupuncture course training in Veterans General Hospital, Taipei, 1997
Certified, Specialist of Pain Medicine, The Chinese Association for the Study of Pain (IASP Chapter), # 0391, 2002
Certified, Specialist of Cardiac Anesthesia, Taiwan Society of Cardiovascular Anesthesia, # 0024, 2002.
Certified, Instructor for Specialist in Pain Medicine, Chinese Association for the Study of Pain (IASP Chapter), # 041, 2005

 

MEMBERSHIPS OF PROFESSIONAL AND SOCIETIES
R.O.C. Board of Anesthesiologists
Taiwan Medical Association
Taipei County Medical Association
Chinese Association for the Study of Pain
Society of Emergency & Critical Care Medicine, Taiwan.
Society for Modern Acupuncture Research
American Society of Anesthesiology
Society for Neuroscience
International Association for the Study of Pain

 

FIELD of SPECIALTY
Pain research, Ultrasound guided regional anesthesia, Pharmacology, Neuroscience.

 

MAJOR AWARDS and HONORS

Young Investigator Award, Chinese Association for the Study of Pain (Taiwan), 2005.

John J. Bonica Trainee Fellowship Award, International Association for the Study of Pain (IASP), 2006.

Research Potential Award, Chinese Association for the Study of Pain (Taiwan), 2007.

Research Prize, Taiwan Pain Society, 2013.

Distinguished Lecture Award,Taiwan Pain Society, 2015.

 

PUBLICATIONS

 

SCI:

  1. Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Jen-Kun Cheng, Yat-Pang Chau, Ting Ruan, Gin-Den Chen, Hsien-Yu Peng. Fbxo3-dependent Fbxl2 ubiquitination mediates neuropathic allodynia through TRAF2/TNIK/GluR1 cascade. The Journal of Neuroscience 2015 Dec; 35(50):16545–16560.
  2. Tzer-Bin Lin, Cheng-Yuan Lai, Ming-Chun Hsieh, Hsueh-Hsiao Wang, Jen-Kun Cheng, Yat-Pang Chau, Gin-Den Chen, Hsien-Yu Peng (2015, Nov). VPS26A-SNX27 interaction-dependent mGluR5 recycling in dorsal horn neurons mediates neuropathic pain in rats. The Journal of Neuroscience 35(44):14943-55.
  3. Tzer-Bin Lin*, Cheng-Yuan Lai, Ming-Chun Hsieh, Jian-Lin Jiang, Jen-Kun Cheng*, Yat-Pang Chau, Ting Ruan, Gin-Den Chen, Hsien-Yu Peng. Neuropathic allodynia involves spinal neurexin-1β-dependent neuroligin-1/postsynaptic density-95/NR2B cascade in rats. Anesthesiology 2015 Oct; 123(4):909-26. (*Co-first author, equal contribution)
  4. Chau-Fu Cheng, Jen-Kun Cheng, Chih-Yang Chen, Ruey-Horng Rau, Yu-Cheng Chang, Meei-Ling Tsaur. (2015, Nov). Nerve growth factor-induced synapse-like structures in contralateral sensory ganglia contribute to chronic mirror-image pain. Pain, 156(11):2295-309.
  5. Bin Huang, Jen-Kun Cheng, Chien-Yi Wug, Ping-Ho Chen, Po-Shu Tua, Yaw-Syan Fu, Chien-Hsing Wu (2015, Aug). Camptothecin promotes the production of nitric oxide that triggers subsequent S-nitrosoproteome-mediated signaling cascades in endothelial cells. Vascular Pharmacology, pii: S1537-1891(15)00174-3.
  6. Yu-Cheng Ho, Jen-Kun Cheng, Lih-Chu Chiou. Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain. The Journal of Physiology 2015 Jul; 593(13): 2955–2973.
  7. L. Chen, M. L. Tsaur, S. W. Wang, T. Y. Wang, Y. C. Hung, C. S. Lin, Y. F. Chang, Y. C. Wang, S. J. Shiue, Jen-Kun Cheng*. Chronic intrathecal infusion of mibefradil, ethosuximide and nickel attenuates nerve ligation-induced pain in rats. British Journal of Anaesthesia 2015 Jul; 115(1):105-11.
  8. Tzer-Bin Lin,  Ming-Chun     Hsieh,      Cheng-Yuan    Lai,  Jen-Kun Cheng, Yat-Pang    Chau, Ting      Ruan,  Gin-Den  Chen,       Hsien-Yu Modulation of Nerve Injury-induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats. Anesthesiology 2015 Jul; 123:199-212.
  9. Chiu HF, Jen-Kun Cheng, Lin PH, Chang JC, Chen IM, Lin CI, Chang WP, Lin CH. A mechanistic study on urine retention in d-amphetamine addicts. Chin J Physiol. 2014 Aug 31; 57(4):171-81.
  10. Shih-Chia Liu, Chi Chen, Ching-Hu Chung, Po-Chuan Wang, Nan-Lin Wu, Jen-Kun Cheng, Yu-Wei Lai, Hui-Lung Sun, Chieh-Yu Peng, Chih-Hsin Tang, Shih-Wei Wang. Inhibitory effects of butein on cancer metastasis and bioenergetics modulation. J Agric Food Chem. 2014 Sep 17; 62(37):9109-17.
  11. Ying-Hua Shieh, Chien-Chuan Chen, Fu-An Li, Jen-Kun Cheng, Ming-Chung Lin, Bin Huang. The translational proteome modulated by 20(S)-protopanaxadiol in endothelial cells. Acta Cardiologica Sinica 2014, 4;30:466- (SCI)
  12. Chau-Fu Cheng*, Jen-Kun Cheng*, Chih-Yang Chen, Cheng-Chang Lien, Dachen Chu, Szu-Yi Wang, Meei-Ling Tsaur. Mirror-image pain is mediated by NGF produced from TNFa-activated satellite glia after peripheral nerve injury. Pain 2014 May;155(5):906-20. (*Co-first author, SCI)
  13. Yu-Chao Liu, Jen-Kun Cheng, Cheng-Chang Lien. Rapid Dynamic Changes of Dendritic Inhibition in the Dentate Gyrus by Presynaptic Activity Patterns. The Journal of Neuroscience 2014 34(4):1344-57. (SCI)
  14. Peng HY, Yeh CM, Jen-Kun Cheng, Chau YP, Ruan T, Chen GD, Hsieh MC, Lai CY, Lin TB. Acute Uterine Irritation Provokes Colonic Motility via Transient Receptor Potential A1-dependent Spinal NR2B Phosphorylation in Rats. Anesthesiology 2014 120(2):436-46. (SCI)
  15. Kuan-Hung Chen, Chung-Ren Lin, Jiin-Tsuey Cheng, Jen-Kun Cheng, Wen-Tzu Liao, Chien-Hui Yang. Altered Mitochondrial ATP Synthase Expression in the Rat Dorsal Root Ganglion After Sciatic Nerve Injury and Analgesic Effects of Intrathecal ATP. Cell Mol Neurobiol 2014 34(1):51-9. (SCI)
  16. Chen KH, Yang CH, Juang SE, Huang HW, Jen-Kun Cheng, Sheen-Chen SM, Cheng JT, Lin CR. Pulsed Radiofrequency Reduced Complete Freund’s Adjuvant-induced Mechanical Hyperalgesia via the Spinal c-Jun N-terminal Kinase Pathway. Cell Mol Neurobiol. 2014 Mar;34(2):195-203. (SCI)
  17. Ming-Chung Lin, Chung-Hsi Hsing, Fu-An Li, Chien-Hsing Wu, Yaw-Syan Fu, Jen-Kun Cheng, Bin Huang.  Rosuvastatin modulates the post-translational acetylome in endothelial cells. Acta Cardiologica Sinica Acta Cardiol Sin 2014;30:67-73. (SCI)
  18. Chan CF, Kuo TW, Weng JY, Lin YC, Chen TY, Cheng JK, Lien CC. Ba2+– and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J Physiol. 2013 Oct 1;591(Pt 19):4843-58.
  19. Yu-Cheng Ho, Jen-Kun Cheng, Lih-Chu Chiou. Hypofunction of glutamatergic neurotransmission in the periaqueductal gray contributes to nerve injury-induced neuropathic pain. The Journal of Neuroscience 2013 May;33(18):7825–7836 (SCI)
  20. Po-Han Chiang, Pu-Yeh Wu, Tzu-Wei Kuo, Yu-Chao Liu, Chu-Fang Chan, Ta-Chun Chien, Jen-Kun Cheng, Yu-Yin Huang, Cheng-Di Chiu, and Cheng-Chang Lien. GABA Is Depolarizing in Hippocampal Dentate Granule Cells of the Adolescent and Adult Rats. Journal of Neuroscience 2012 Jan 4;32(1):62-67. (SCI)
  21. Wen YR, Tan PH, Jen-Kun Cheng, Liu YC, Ji RR. Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc. 2011 Aug;110(8):487-94 (review, SCI)
  22. Li-Chuan Chu, Meei-Ling Tsaur, Chia-Shiang Lin, Yu-Chun Hung, Tao-Yeuan Wang, Chien-Chuan Chen, Jen-Kun Cheng*. Chronic intrathecal infusion of gabapentin prevents nerve ligation-induced pain in rats. British Journal of Anaesthesia 2011 May;106(5):699-705. (SCI) (*corresponding author)
  23. Chia-Shiang Lin,* Jen-Kun Cheng,* Yung-Wei Hsu, Chien-Chuan Chen, Hsuan-Chih Lao, Chun-Jen Huang, Peter H. Cheng, Samer Narouze. Ultrasound-Guided Ganglion Impar Block: A Technical Report. Pain Medicine 2010 11(3):390-4. (*first authors of equal contribution) (SCI)
  24. Yong-Jing Gao,* Jen-Kun Cheng,* Qing Zeng, Zhen-Zhong Xu, Isabelle Decosterd, Xiaoyin Xu, Ru-Rong Ji. Selective inhibition of JNK with a peptide inhibitor attenuates pain hypersensitivity and tumor growth in a mouse skin cancer pain model. Experimental Neurology 2009 Sep;219(1):146-55. (*first authors of equal contribution) (SCI)
  25. Chih-Fu Lin, Meei-Ling Tsaur, Chia-Shiang Lin, Chien-Chuan Chen, Yung-Jen Huang, Jen-Kun Cheng*. Intrathecal gabapentin does not act as an HCN channel activator in the rat formalin test. 2009 European Journal of Anesthesiology 2009;26(10):821-4. (*corresponding author) (SCI)
  26. Hung YC, Suzuki S, Chen CC, Pan YY, Wang TY, Jen-Kun Cheng, Wang GK, Gerner P. Calcium chloride prolongs the effects of lidocaine and bupivacaine in rat sciatic nerve. Reg Anesth Pain Med. 2009 34(4):333-9. (SCI)
  27. Yasuhiko Kawasaki,* Ling Zhang,* Jen-Kun Cheng, Ru-Rong Ji. Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. Journal of Neuroscience 2008 14;28(20):5189-94. (*first authors of equal contribution) (SCI)
  28. Tatsuro Kohno,* Haibin Wang,* Fumimasa Amaya, Gary J. Brenner, Jen-Kun Cheng, Ru-Rong Ji, Clifford J. Woolf. Bradykinin enhances AMPA and NMDA receptor activity in spinal cord dorsal horn neurons by activating multiple kinases to produce pain hypersensitivity. Journal of Neuroscience 2008 23;28(17):4533-40. (*first authors of equal contribution) (SCI)
  29. Jen-Kun Cheng, Ru-Rong Ji. Intracellular signaling in primary sensory neurons and persistent pain. Neurochemical Research 2008 33(10):1970-8. (review) (SCI)
  30. Li-Ying Chien*, Jen-Kun Cheng*, Dachen Chu, Chau-Fu Cheng, Meei-Ling Tsaur. Reduced Expression of A-type Potassium Channels in Primary Sensory Neurons Induces Mechanical Hypersensitivity. The Journal of Neuroscience 2007 27(37):9855-9865. (*first authors of equal contribution) (SCI)
  31. Yu-Chun Hung, Chia-Ying Chen, Philipp Lirk, Chi-Fei Wang, Jen-Kun Cheng, Chien-Chuan Chen, Ging Kuo Wang, Peter Gerner. Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic nerve block. Regional Anesthesia and Pain Medicine 2007; 32(4):288-95. (SCI)
  32. Lin CS, Tsaur ML, Chen CC, Wang TY, Lin CF, Lai YL, Hsu TC, Pan YY, Yang CH, Jen-Kun Cheng.* Chronic intrathecal infusion of minocycline prevents the development of spinal nerve ligation-induced pain in rats. Regional Anesthesia and Pain Medicine 2007 May-Jun;32(3):209-16. (*corresponding author)
  33. Jen-Kun Cheng, Chia-Shiang Lin, Chien-Chuan Chen, Jia-Rung Yang, Lih-Chu Chiou. Effects of Intrathecal Injection of T-Type Calcium Channel Blockers in the Rat Formalin Test. Behavioural Pharmacology 2007; 18(1):1-8. (SCI, supported by NSC 94-2314-B-195 –006)

 

Non- SCI:

  1. Ping-Heng Tan, Yun-Ying Pao, Jen-Kun Cheng, Kuo-Chuan Hung, Chien-Cheng Liu. MicroRNA-based therapy in pain medicine: Current progress and future prospects. Acta Anaesthesiologica Taiwanica 2013 (51): 171-176.
  2. Jen-Kun Cheng. Repetitive transcranial magnetic stimulationd – An alternative treatment for chronic refractory pain. Acta Anaesthesiologica Taiwanica 2013 (51): 51–52. (Editorial review)
  3. Szu-Ling Chang, Hsuan-Chih Lao, Chien-Chuan Chen, Yu-Chun Hung, Jen-Kun Cheng, Chia-Shiang Lin. Optimal Timing to Perform Epidural Blood Patch for the Case of Spontaneous Intracranial Hypotension Complicated with Delayed Subdural Hematoma-A Case Report. Chinese Journal of Pain 2013 23(1): 35-41.
  4. Chia-Ying Chen, Ruey-Horng Rau, Jei-Yu Huang, Jen-Kun Cheng. Patient Controlled Analgesia (PCA) in the Elderly-A Retrospective Study in the Medical Center. Chinese Journal of Pain 2012 22(2): 63-72.
  5. Huang CC, Hsu HH, Huang JY, Lao HC, Cheng JK, Chen CC, Lin CS. Treating a patient with intractable paralytic ileus using thoracic epidural analgesia. Acta Anaesthesiol Taiwan 2012 Jun;50(2):78-80.
  6. CH Wang, CL Yang, HC Lao, Jen-Kun Cheng, CC Chen, CS Lin. Treatment of spontaneous intracranial hypotension secondary to sacral perineural cysts by caudal epidural blood patch – a case report. Chinese Journal of Pain 2011 21(1): 26-31
  7. Chiun-Ting Chen, Chih-Lin Yang, Hsuan-Chih Lao, Yung-Wei Hsu,Yu-Chun Hung, Jen-Kun Cheng, Chien-Chuan Chen, Chia-Shiang Lin. Ultrasound-Guided Intercostal Nerve Block for Intractable Right Upper Quadrant Abdominal Pain : A Case Report. Chinese Journal of Pain 2010 20(2):77-82.
  8. Chih-Lin Yang, Hsuan-Chih Lao, Yung-Wei Hsu, Yu-Chun Hung, Jen-Kun Cheng, Chien-Chuan Chen, Chia-Shiang Lin. Ultrasound-Guided Pulsed Radiofrequency of Suprascapular Nerve for Chronic Shoulder Pain: A Case Report. Chinese Journal of Pain 2010 20(2):83-92.

 

Books and Chapters

  1. Jen-Kun Cheng. Intrathecal Studies on Animal Pain Models. Pain Management

– Current Issues and Opinions. InTech. Jan, 2012: P3-P26.

  1. Jen-Kun Cheng(2009)。Current advances in neuropathic pain research–focusing on voltage-gated ion channels。Nociceptive and Neuropathic Pain: Mechanisms and Treatments(77-91)。(Research Signpost)。

 

Public Services:

Councilor and Supervisor, Chairman of Examination Board (2013-2014) Taiwan Society of Anesthesiologists

Councilor and Supervisor, Taiwan Pain Society

Chairman, 2013 Annual Meeting of Taiwan Pain Society, Taipei, Taiwan

Committee, invited speaker and moderator, 2nd Asian Congress on Pain, 2014 AAFPS (Asian Australasian Federation of Pain Societies), Taipei, Taiwan.

 

Journal Reviewer:

Biochemical Pharmacology, Life Sciences, Anesthesiology,

Taiwanese Journal of Obstetrics and Gynecology, Acta Anaesthesiologica Taiwanica

Journal of Pharmacy and Bioallied Sciences, BJA, Behavioural Pharmacology, International Journal of Medicine and Medical Science

Journal of the Chinese Medical Association, International Journal of Gerontology

 

Editorial Board Members:

The Chinese Journal of Pain, World Journal of Anesthesiology

 

Taiwan NSC project reviewer: 2005, 2006, 2007, 2009, 2010, 2013, 2014.

科技部Review committee複審委員2013, 2015

 

科技部Research Funding

年度 計畫名稱
103 大麻受體在神經受損引發慢性疼痛之角色及與 CaV3.2可能之交互作用
101 Cav3.2 及 Nav1.6 在神經受損慢性疼痛的角色
98 鈉鈣交換器與T型鈣離子通道在L5/6脊神經結紮後疼痛成形的角色
95 Kv4型鉀離子通道在神經病變疼痛之角色
94 T型鈣離子通道阻斷劑在老鼠福馬林及神經病變疼痛模式的止痛作用及對脊髓Fos蛋白表現的影響
93 脊髓腔中鈉離子通道阻斷劑在老鼠神經病變與發炎性疼痛模式的止痛效果及與Gabapentin和COX-2 Inhibitor NS-398 的相互作用
92 在老鼠術後疼痛模式中, K(ATP) channel 與 NMDA receptor 於脊髓腔內gabapentin之抗觸痛作用所扮演的角色

 Renew: 2015/12/28